Over the last decade, Drs. Deal and Jones have been discussing the need for decontaminating the air in shared spaces, especially in the hospital setting, to reduce the spread of nosocomial, airborne infections. The doctors were distressed by the thought of vulnerable individuals breathing contaminated, shared air in the emergency department or radiology suite. In early 2020 when the SARS co-V – 2 coronavirus pandemic began, they knew they had to intervene. Taking opportunity to act on the previous decade of thoughts and plans, the Optuvus RM 23 air decontamination unit was born. Multiple variations of this technology have been adapted to create rapid and efficient decontamination of shared air. The ability to quickly make negative pressure isolation rooms with continuous air cleaning using germicidal ultraviolet light, cold plasma, HEPA filtration and organic monoterpene phenols has given hospitals a new tool to take care of surges of contagious illnesses. These technologies have been employed to protect staff and patients in places like the COVID infusion center, conference rooms, doctor’s offices, and the homes of immunocompromised patients going through chemotherapy.